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新規強心薬SCH00013のモルモット心臓に対する作用
https://doi.org/10.15012/00000754
https://doi.org/10.15012/00000754a8d2060f-c813-4f59-b882-148c6e56a7eb
名前 / ファイル | ライセンス | アクション |
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jinbun_vol5301_03.pdf (2.1 MB)
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Copyright (c) 2016 齊藤久美子, 酒井淳一, 堀田芳弘
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2016-08-23 | |||||
タイトル | ||||||
タイトル | 新規強心薬SCH00013のモルモット心臓に対する作用 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Actions of a New Cardiotonic Agent, SCH00013, on Guinea-pig Heart | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | SCH00013 | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | positive inotropic effect (PIE) | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | negative inotropic effects (NIE) | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | positive chronotropic effect (PCE) | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | heart rate (HR) | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
ID登録 | ||||||
ID登録 | 10.15012/00000754 | |||||
ID登録タイプ | JaLC | |||||
その他(別言語等)のタイトル | ||||||
その他のタイトル | シンキキョウシンヤクSCH00013ノモルモットシンゾウニタイスルサヨウ | |||||
著者 |
齊藤, 久美子
× 齊藤, 久美子× 酒井, 淳一× 堀田, 芳弘 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | A new cardiotonic agent, SCH00013 (SCH), which was synthesized by Zenyaku Kogyo Company, Limited, exhibits cardiotonic effects by enhancing calcium sensitivity [1]. In this study, we examined the inotropic and chronotropic effects of SCH usin right atrial muscles extirpated from guinea pigs. Although 10 - 4 M SCH showed positive inotropic effects (50% of those of noradrenaline (NAd)), there was no increase in the heart rate. In addition, we measured changes in the left ventricular diastolic pressure (LVDP) and transient Ca 2 + (TCa) signals in Fura-2-loaded Langendorff hearts. The administration of 10 -5 M SCH decreased the level of TCa, whereas 10 - 4 M SCH administration increased it. On the other hand, pimobendan (PIM), which is used as a drug for heart failure due to its calcium sensitivity-enhancing actions, decreased the level of TCa at 10 - 4 M despite an increase in contractility. This suggests that the mechanism of Ca 2+ contractile protein system sensitivity differs between SCH and PIM. As SCH does not increase the heart rate in the presence of heart failure, it may protect the cardiac muscle. | |||||
書誌情報 |
名古屋学院大学論集 人文・自然科学篇 en : THE NAGOYA GAKUIN DAIGAKU RONSHU; Journal of Nagoya Gakuin University; HUMANITIES and NATURAL SCIENCES 巻 53, 号 1, p. 23-33, 発行日 2016-07-31 |
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出版者 | ||||||
出版者 | 名古屋学院大学総合研究所 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0385-0056 |