{"created":"2023-06-19T09:37:13.701467+00:00","id":765,"links":{},"metadata":{"_buckets":{"deposit":"99dd7d91-c1bc-4c99-ac1b-e3e42a670147"},"_deposit":{"created_by":2,"id":"765","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"765"},"status":"published"},"_oai":{"id":"oai:ngu.repo.nii.ac.jp:00000765","sets":["1:12:130"]},"author_link":["1144","2188","44"],"item_10002_alternative_title_1":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"シンキキョウシンヤクＳＣＨ00013ノモルモットシンゾウニタイスルサヨウ"}]},"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-07-31","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"33","bibliographicPageStart":"23","bibliographicVolumeNumber":"53","bibliographic_titles":[{"bibliographic_title":"名古屋学院大学論集　人文・自然科学篇"},{"bibliographic_title":"THE NAGOYA GAKUIN DAIGAKU RONSHU; Journal of Nagoya Gakuin University; HUMANITIES and NATURAL SCIENCES","bibliographic_titleLang":"en"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":" 　A new cardiotonic agent, SCH00013 (SCH), which was synthesized by Zenyaku Kogyo Company, Limited, exhibits cardiotonic effects by enhancing calcium sensitivity [1]. In this study, we examined the inotropic and chronotropic effects of SCH usin right atrial muscles extirpated from guinea pigs. Although 10 － 4 M SCH showed positive inotropic effects (50% of those of noradrenaline (NAd)), there was no increase in the heart rate. In addition, we measured changes in the left ventricular diastolic pressure (LVDP) and transient Ca 2 ＋ (TCa) signals in Fura-2-loaded Langendorff hearts. The administration of 10 －5 M SCH decreased the level of TCa, whereas 10 － 4 M SCH administration increased it. On the other hand, pimobendan (PIM), which is used as a drug for heart failure due to its calcium sensitivity-enhancing actions, decreased the level of TCa at 10 － 4 M despite an increase in contractility. This suggests that the mechanism of Ca 2＋ contractile protein system sensitivity differs between SCH and PIM. As SCH does not increase the heart rate in the presence of heart failure, it may protect the cardiac muscle.","subitem_description_type":"Abstract"}]},"item_10002_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.15012/00000754","subitem_identifier_reg_type":"JaLC"}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"名古屋学院大学総合研究所"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0385-0056","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"齊藤, 久美子"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"酒井, 淳一"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"堀田, 芳弘"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-08-23"}],"displaytype":"detail","filename":"jinbun_vol5301_03.pdf","filesize":[{"value":"2.1 MB"}],"format":"application/pdf","license_note":"Copyright (c) 2016 齊藤久美子, 酒井淳一, 堀田芳弘","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"jinbun_vol5301_03.pdf","url":"https://ngu.repo.nii.ac.jp/record/765/files/jinbun_vol5301_03.pdf"},"version_id":"6905ed20-95ca-4b9e-8743-e7ae82d42f16"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"SCH00013","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"positive inotropic effect (PIE)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"negative inotropic effects (NIE)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"positive chronotropic effect (PCE)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"heart rate (HR)","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"新規強心薬SCH00013のモルモット心臓に対する作用","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"新規強心薬SCH00013のモルモット心臓に対する作用"},{"subitem_title":"Actions of a New Cardiotonic Agent, SCH00013, on Guinea-pig Heart","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"2","path":["130"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-08-23"},"publish_date":"2016-08-23","publish_status":"0","recid":"765","relation_version_is_last":true,"title":["新規強心薬SCH00013のモルモット心臓に対する作用"],"weko_creator_id":"2","weko_shared_id":2},"updated":"2023-06-19T10:02:53.365412+00:00"}