{"created":"2023-06-19T09:37:34.023677+00:00","id":1333,"links":{},"metadata":{"_buckets":{"deposit":"c280b9b0-2691-4ff1-8de6-0fba6f69b9cb"},"_deposit":{"created_by":27,"id":"1333","owners":[27],"pid":{"revision_id":0,"type":"depid","value":"1333"},"status":"published"},"_oai":{"id":"oai:ngu.repo.nii.ac.jp:00001333","sets":["1:12:278"]},"author_link":["2114","2113","1729","33","32","2115"],"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-01-31","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"35","bibliographicPageStart":"29","bibliographicVolumeNumber":"57","bibliographic_titles":[{"bibliographic_title":"名古屋学院大学論集　人文・自然科学篇"},{"bibliographic_title":"THE NAGOYA GAKUIN DAIGAKU RONSHU; Journal of Nagoya Gakuin University; HUMANITIES and NATURAL SCIENCES","bibliographic_titleLang":"en"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"A plant in the Lamiaceae family, rosemary ( Rosmarinus officinalis ) is a perennial shrub native to the Mediterranean region. The current study used right atrial specimens from guinea pigs to assess the biological activity of 3 catechol diterpenes with an abietane skeleton―carnosic acid (CA ― 1), demethylsalvicanol (DS ― 1), and carnosol (CN ― 1)―contained in rosemary. Administration of CA ― 1 had a positive inotropic effect (PIE) while administration of CN ― 1 conversely had a negative inotropic effect (NIE). Administration of DS ― 1 resulted in no changes in myocardial contractility. Administration of CA ― 1 or DS ― 1 did not result in significant changes in heart rate. However, administration of CN ― 1 had a negative chronotropic effect (NCE), and administration of CN ― 1 at a final concentration of 10 － 4 M caused cardiac arrest. In addition, the PIE of CA ― 1 was inhibited by prior administration of the phosphodiesterase (PDE) inhibitor IBMX (5 μM).","subitem_description_type":"Abstract"}]},"item_10002_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.15012/00001296","subitem_identifier_reg_type":"JaLC"}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"名古屋学院大学総合研究所"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0385-0056","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Mitsui-Saitoh, Kumiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Aoyagi, Yutaka"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hitotsuyanagi, Yukio"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takeya, Koichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sakai, Junichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hotta, Yoshihiro"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-02-08"}],"displaytype":"detail","filename":"jinbun_vol5702_03.pdf","filesize":[{"value":"284.7 kB"}],"format":"application/pdf","license_note":"Copyright (c) 2020 Saitoh-Mitsui Kumiko,Aoyagi Yutaka,Hitotsuyanagi Yukio,Takeya Koichi,Sakai Junichi,Hotta Yoshihiro","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"jinbun_vol5702_03","url":"https://ngu.repo.nii.ac.jp/record/1333/files/jinbun_vol5702_03.pdf"},"version_id":"1bc745c4-abe1-4206-9685-127191e210e5"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Abietane diterpenes","subitem_subject_scheme":"Other"},{"subitem_subject":"Positive inotropic effect (PIE)","subitem_subject_scheme":"Other"},{"subitem_subject":"Negative inotropic effect (NIE)","subitem_subject_scheme":"Other"},{"subitem_subject":"Negative chronotropic effect (NCE)","subitem_subject_scheme":"Other"},{"subitem_subject":"heart rate (HR)","subitem_subject_scheme":"Other"},{"subitem_subject":"Abietane diterpenes","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Positive inotropic effect (PIE)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Negative inotropic effect (NIE)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Negative chronotropic effect (NCE)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"heart rate (HR)","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Effects of Abietane diterpenes from Rosmarinus officinalis on guinea pig hearts","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effects of Abietane diterpenes from Rosmarinus officinalis on guinea pig hearts"},{"subitem_title":"Effects of Abietane diterpenes from Rosmarinus officinalis on guinea pig hearts","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"27","path":["278"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-02-10"},"publish_date":"2021-02-10","publish_status":"0","recid":"1333","relation_version_is_last":true,"title":["Effects of Abietane diterpenes from Rosmarinus officinalis on guinea pig hearts"],"weko_creator_id":"27","weko_shared_id":-1},"updated":"2023-06-19T10:02:34.925593+00:00"}