@article{oai:ngu.repo.nii.ac.jp:00001333,
 author = {Mitsui-Saitoh, Kumiko and Aoyagi, Yutaka and Hitotsuyanagi, Yukio and Takeya, Koichi and Sakai, Junichi and Hotta, Yoshihiro},
 issue = {2},
 journal = {名古屋学院大学論集　人文・自然科学篇, THE NAGOYA GAKUIN DAIGAKU RONSHU; Journal of Nagoya Gakuin University; HUMANITIES and NATURAL SCIENCES},
 month = {Jan},
 note = {A plant in the Lamiaceae family, rosemary ( Rosmarinus officinalis ) is a perennial shrub native to the Mediterranean region. The current study used right atrial specimens from guinea pigs to assess the biological activity of 3 catechol diterpenes with an abietane skeleton―carnosic acid (CA ― 1), demethylsalvicanol (DS ― 1), and carnosol (CN ― 1)―contained in rosemary. Administration of CA ― 1 had a positive inotropic effect (PIE) while administration of CN ― 1 conversely had a negative inotropic effect (NIE). Administration of DS ― 1 resulted in no changes in myocardial contractility. Administration of CA ― 1 or DS ― 1 did not result in significant changes in heart rate. However, administration of CN ― 1 had a negative chronotropic effect (NCE), and administration of CN ― 1 at a final concentration of 10 － 4 M caused cardiac arrest. In addition, the PIE of CA ― 1 was inhibited by prior administration of the phosphodiesterase (PDE) inhibitor IBMX (5 μM).},
 pages = {29--35},
 title = {Effects of Abietane diterpenes from Rosmarinus officinalis on guinea pig hearts},
 volume = {57},
 year = {2021}
}