{"created":"2023-06-19T09:37:31.477867+00:00","id":1268,"links":{},"metadata":{"_buckets":{"deposit":"91a5a99f-8998-4db3-868b-4174164fb24b"},"_deposit":{"created_by":2,"id":"1268","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"1268"},"status":"published"},"_oai":{"id":"oai:ngu.repo.nii.ac.jp:00001268","sets":["1:24:268"]},"author_link":["2176","1849","24","2173","2174","2175","2172","2171"],"item_10002_alternative_title_1":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"サイシュウブンカシタキンサイボウヘノキンエイセイサイボウノトリコミモデル"}]},"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-03-31","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"15","bibliographicPageStart":"1","bibliographicVolumeNumber":"8","bibliographic_titles":[{"bibliographic_title":"名古屋学院大学論集　医学・健康科学・スポーツ科学篇"},{"bibliographic_title":"THE NAGOYA GAKUIN DAIGAKU RONSHU; Journal of Nagoya Gakuin University; MEDICAL, HEALTH, and SPORTS SCIENCES","bibliographic_titleLang":"en"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"　適切な負荷量で筋収縮を行うと筋肥大が生じる。しかし，筋収縮の何が引き金となり，どの細胞内シグナルを経て筋肥大に至るのか解明されていない。一方で，筋肥大や筋萎縮からの回復促進時に筋線維核数が大幅に増加することが知られている。この核数増加には既存の筋線維への筋衛星細胞の取り込みが関与すると考えられるが，成熟後の筋線維において筋衛星細胞が取り込まれるか否かは様々な報告により見解が分かれている。そこで本研究は，初代培養筋管細胞の筋収縮活動モデルを確立し，そのモデルにGreen Fluorescent Protein （GFP）標識した筋衛星細胞を添加・共培養することで，筋管成熟後の筋衛星細胞取り込みを観察した。その結果，筋収縮を行うとGFP 陽性の筋管細胞が多く観察され，刺激下の培養筋管細胞で筋衛星細胞の取り込みが再現できた。このモデルを用いれば，今後筋衛星細胞の取り込みのメカニズムの一端が解明できる。","subitem_description_type":"Abstract"}]},"item_10002_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.15012/00001239","subitem_identifier_reg_type":"JaLC"}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"名古屋学院大学総合研究所"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2187-5162","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"伊東, 佑太"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"伊藤, 晃慎"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"二之宮, 宏人"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"丹羽, 弘貴"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"名和, 礼乃"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"原田, 志保"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"富士井, 里紗"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-04-13"}],"displaytype":"detail","filename":"igakukenkou_vol0802_01.pdf","filesize":[{"value":"3.0 MB"}],"format":"application/pdf","license_note":"Copyright (c) 2019 伊東佑太, 伊藤晃慎,二之宮宏人,丹羽弘貴,名和礼乃,原田志保,冨士井里紗","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"igakukenkou_vol0802_01.pdf","url":"https://ngu.repo.nii.ac.jp/record/1268/files/igakukenkou_vol0802_01.pdf"},"version_id":"d2c75ecc-1edd-41cc-923f-0a203eb81ffe"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"筋衛星細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"取り込み","subitem_subject_scheme":"Other"},{"subitem_subject":"筋線維核数","subitem_subject_scheme":"Other"},{"subitem_subject":"筋肥大","subitem_subject_scheme":"Other"},{"subitem_subject":"myogenic satellite cells","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"fusion","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"myonuclei","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"muscle hypertrophy","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"最終分化した筋細胞への筋衛星細胞の取り込みモデル","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"最終分化した筋細胞への筋衛星細胞の取り込みモデル"},{"subitem_title":"A model of myogenic satellite cell fusion to myotubes","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"2","path":["268"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-04-13"},"publish_date":"2020-04-13","publish_status":"0","recid":"1268","relation_version_is_last":true,"title":["最終分化した筋細胞への筋衛星細胞の取り込みモデル"],"weko_creator_id":"2","weko_shared_id":2},"updated":"2023-06-19T10:03:01.405058+00:00"}