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機械的損傷の程度の違いがカルボニルストレス発現に及ぼす影響
https://doi.org/10.15012/00000924
https://doi.org/10.15012/000009241f881e6f-685e-4395-9e5d-0f89040f213c
名前 / ファイル | ライセンス | アクション |
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igakukenkou_vol0502_02.pdf (704.8 kB)
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Copyright (c) 2017 日比野至,サイモンタング
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2017-04-18 | |||||
タイトル | ||||||
タイトル | 機械的損傷の程度の違いがカルボニルストレス発現に及ぼす影響 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Differential Carbonyl Stress Expression in the Intervertebral Disc between Singular- and Persistent- Mechanical Injuries | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 腰痛 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 椎間板 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 機械的損傷 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | カルボニルストレス | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Low back pain | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Intervertebral disc degeneration | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Mechanical injury | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Carbonyl stress | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
ID登録 | ||||||
ID登録 | 10.15012/00000924 | |||||
ID登録タイプ | JaLC | |||||
その他(別言語等)のタイトル | ||||||
その他のタイトル | キカイテキソンショウノテイドノチガイガカルボニルストレスハツゲンニオヨボスエイキョウ | |||||
著者 |
日比野, 至
× 日比野, 至× サイモン, タング |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Low back pain is a significant public health problem worldwide. Intervertebral disc degeneration is most significant known risk factor for low back pain. Yet the mechanisms of degeneration remain relatively unknown. Carbonyl stress and oxidation have been implicated in cartilage and fibrocartilage degeneration. Here we investigate the role of oxidative stress and carbonyl production in the intervertebral disc after mechanical injury using an in vitro organ model of the mouse functional spine unit. We use a single- stab insult to model mild injury, and the three- stab insult to model severe trauma. Our results indicate that mild injury increases the carbonyl response that may be required for tissue repair, while severe trauma tempers this response and rapidly accelerates degeneration. | |||||
書誌情報 |
名古屋学院大学論集 医学・健康科学・スポーツ科学篇 en : THE NAGOYA GAKUIN DAIGAKU RONSHU; Journal of Nagoya Gakuin University; MEDICAL, HEALTH, and SPORTS SCIENCES\n 巻 5, 号 2, p. 11-19, 発行日 2017-03-31 |
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出版者 | ||||||
出版者 | 名古屋学院大学総合研究所 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2187-5162 |